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Research Type
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Pure and Applied Science / Translational |
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Keywords
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inflammation refractory detrusor overactivety infection |
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Target Audience
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Urogynaecology and Female & Functional Urology |
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Aims and Objectives
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Approximately 35% of patients with detrusor overactivity are unresponsive to current antimuscarinic; these Refractory patients are a hard core group of sufferers. Recent studies from London, Sydney and Chicago have indicated that refractory patients are more likely to have bacteriuria, and changes in their microbiome, which are associated with a poor response to treatment. In the last 3 years, basic scientists and clinicians have made significant advances in our knowledge about the relationship between inflammation, molecular signalling of "urgency" , with pathophysiological changes in the immune response, leading to urge incontinence. This workshop will bring together scientists and clinicians to discuss these recent findings.
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