Is prostatic urethral lift beneficial treatment for patients with multiple comorbidities?

Ahn S1, Shim J1, Han J2, Oh M1, Moon D1

Research Type

Clinical

Abstract Category

Male Lower Urinary Tract Symptoms (LUTS) / Voiding Dysfunction

Abstract 443
Prostate & Urethra
Scientific Podium Short Oral Session 28
Saturday 10th September 2022
10:35 - 10:42
Hall K2
Benign Prostatic Hyperplasia (BPH) Surgery Retrospective Study
1. Department of Urology, Korea University College of Medicine, 2. Department of Urology, Seongnam Citizens Medical Center
In-Person
Presenter
Links

Abstract

Hypothesis / aims of study
Prostatic urethral lift (PUL) can be performed in patients at high risk for general anesthesia due to multiple comorbidities, under local anesthesia. However, the clinical efficacy of PULs in patients with multiple comorbidities remains unknown. Therefore, this study aimed to evaluate the clinical efficacy of PUL in patients with multiple comorbidities by comparing the clinical efficacy in these patients with that in healthy individuals.
Study design, materials and methods
We performed a retrospective observational cohort study, in which patients who underwent PUL between December 2016 and January 2019 at a single tertiary care center were categorized into two groups: healthy individuals who wanted to preserve sexual function (Group 1) and patients with high comorbidities who were at high risk for general anesthesia based on an American Society of Anesthesiologists (ASA) score of ≥3 (Group 2). The International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), post-void residual urine (PVR), International Index of Erectile Function-5 (IIEF-5), and Male Sexual Health Questionnaire for Ejaculatory Dysfunction Short Form (MSHQ-EjD) were obtained preoperatively and compared throughout the 2-year follow-up. This study was approved by Ethical Committee of the Korea University Hospital.
Results
Sixty-six patients were included in this study, of whom 36 were stratified as healthy individuals who underwent PUL for preserving ejaculatory function (Group 1) and 30 as having high comorbidity and underwent PUL under local anesthesia (Group 2). There were significant differences in patient age (Group 1 vs Group 2: 60.7±5.3 vs75.3±8.1, p<0.001) and comorbidities based on group classification characteristics; however, there were no differences between the groups regarding prostate volume, symptom severity, and deployed implants.
Interpretation of results
In Group 1, IPSS, IPSS quality of life (QoL), and Qmax were significantly improved and main-tained during follow-up, whereas in Group 2, improvements in these parameters were not maintained during follow-up, except for IPSS QoL (Table 1.). In both groups, there was no significant decline in ejaculatory and sexual parameters (assessed by IIEF and MSHQ scores) over the course of the 2-year and 1-year follow-up, respectively. Eleven patients (36%) in Group 2 required additional treatment for the recurrence of lower urinary tract symptoms.
Concluding message
Patients with multiple comorbidities had a low therapeutic effect after PUL, suggesting a high rate of treatment failure. This study suggests that comorbidity status should be considered when evaluating the expected benefits for PUL in preoperative counseling. Although PUL is a conceivable alternative in patients at a high risk for general anesthesia due to comorbidities, it should be recognized that severe and multiple comorbidities can lead to treatment failure after PUL. Future studies based on new concepts introduced in recent years should aim to determine whether other minimally invasive treatments are indeed beneficial for these patients.
Figure 1 Table 1
Disclosures
Funding None Clinical Trial No Subjects Human Ethics Committee Institutional Review Board of Korea University Guro Hospital Helsinki Yes Informed Consent No
Citation

Continence 2S2 (2022) 100417
DOI: 10.1016/j.cont.2022.100417

08/11/2024 15:48:42