Platelet-rich plasma (PRP) is enriched with growth factors that promote tissue regeneration and has shown potential therapeutic benefits in various medical conditions, including erectile dysfunction (ED). This study aimed to assess the safety and efficacy of PRP therapy as an adjunct to standard medical treatment for organic ED compared to medical treatment alone.

This was a retrospective analysis of a prospectively maintained database, evaluating the clinical outcomes of PRP therapy in patients with organic ED.  A total of 60 male patients diagnosed with organic ED were included in the study and divided into two groups: Group A (n = 30): Received standard medical treatment and  Group B (n = 30): Received standard medical treatment in combination with PRP therapy. PRP treatment consisted of four weekly injections followed by two additional biweekly injections. The effectiveness of treatment was assessed using the International Index of Erectile Function-5 (IIEF-5) and the Erection Hardness Score (EHS) at a 3-month follow-up.

Baseline characteristics, including age, smoking status, and comorbidities (diabetes mellitus and cardiovascular disease), were comparable between groups (P > 0.05). Both groups showed significant improvement in erectile function at the 3-month follow-up. However, Group B demonstrated superior outcomes: EHS Score: Group B (3.23 ± 0.85) vs. Group A (2.73 ± 1.25), P = 0.003 and 
IIEF-5 Score: Group B (19.73 ± 3.93) vs. Group A (17.73 ± 6.56), P < 0.001. No adverse events related to PRP therapy were reported during the follow-up period.

The findings indicate that PRP, when combined with standard medical therapy, leads to significantly greater improvements in erectile function compared to medical treatment alone. The enhanced outcomes, reflected in higher EHS and IIEF-5 scores, suggest that PRP may have a positive impact on erectile tissue regeneration and function.

PRP therapy appears to be a safe and effective adjunct to standard medical treatment for organic ED, demonstrating superior erectile function outcomes at 3 months compared to medical therapy alone. Further large-scale, long-term studies are warranted to validate these findings and explore the full therapeutic potential of PRP in ED management.